| Title | Triple Stimulus-Responsive Polypeptide Nanoparticles That Enhance Intratumoral Spatial Distribution |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Callahan, DJ, Liu, W, Li, X, Dreher, MR, Hassouneh, W, Kim, M, Marszalek, P, Chilkoti, A |
| Journal | Nano Letters |
| Date Published | 03/2012 |
| ISSN | 1530-6992 |
| Abstract | To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control. |
| DOI | 10.1021/nl300630c |
| Short Title | Nano Lett. |
