|Title||Triple Stimulus-Responsive Polypeptide Nanoparticles That Enhance Intratumoral Spatial Distribution|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Callahan, DJ, Liu, W, Li, X, Dreher, MR, Hassouneh, W, Kim, M, Marszalek, P, Chilkoti, A|
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.
|Short Title||Nano Lett.|