| Title | Nanoparticulate drug delivery systems |
| Publication Type | Patent |
| Year of Publication | 2021 |
| Authors | Yousefpour, P, Chilkoti, A |
| Patent Version Number | US20210316007A1 |
| International Patent Classification | A1 |
| International Patent Number | 20210316007 |
| Application Number | 17/272887 |
| Date Published | 10/14/2021 |
| Abstract | Described herein are compositions that include an assembly of self-assembling conjugates. The self-assembling conju gates may include a polypeptide having a transition tem perature (17) above 50 C. when the polypeptide is not attached to the conjugate, an albumin binding domain (ABD) attached to a first end of the polypeptide, and at least one molecule attached to a second end of the polypeptide through a cysteine group, wherein the molecule has an octanol-water distribution coefficient (log D) of greater than or equal to 1.5 at a pH of 7.4 when the molecule is not attached to the conjugate. Also described herein are methods of using the compositions. |