Title | Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery |
Publication Type | Review Article |
Authors | MacEwan, SR, Callahan, DJ, Chilkoti, A |
Secondary Title | Nanomedicine |
Year of Publication | 2010 |
Volume | 5 |
Pagination | 793 - 806 |
Date Published | 07/2010 |
Abstract | Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in ‘smart’ – stimulus-responsive – peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug. |
Issue | 5 |
Short Title | Nanomedicine |
Citation Key | 217 |
ISSN Number | 1748-6963 |
DOI | 10.2217/nnm.10.50 |