Therapeutic agents comprising a BMP-9 peptide and eleastin-like peptides

TitleTherapeutic agents comprising a BMP-9 peptide and eleastin-like peptides
Publication TypePatent
Year of Publication2021
AuthorsChilkoti, A
Date Published08/31/2021
AssigneeDuke University
Patent Number11103558
Abstract

The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.