Chilkoti Group

The Chilkoti group carries out research in two areas: (1) Biomolecular Materials, with a focus on genetically encoded stimulus responsive peptide polymers and fusion proteins for application in protein purification and drug delivery; and (2) Biointerface Science, with a focus on protein-polymer conjugates, the development of low-cost, point-of-care clinical diagnostics, and plasmonic biosensors.

Recent Publications

P. Yousefpour, McDaniel, J. R. , Prasad, V. , Ahn, L. , Li, X. , Subrahmanyan, R. , Weitzhandler, I. , Suter, S. , and Chilkoti, A. , Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy, Nano Letters, vol. 18, no. 12, pp. 7784 - 7793, 2018.
D. Mozhdehi, Luginbuhl, K. M. , Dzuricky, M. , Costa, S. A. , Xiong, S. , Huang, F. C. , Lewis, M. M. , Zelenetz, S. R. , Colby, C. D. , and Chilkoti, A. , Genetically Encoded Cholesterol-Modified Polypeptides, Journal of the American Chemical Society, vol. 141, no. 2, pp. 945 - 951, 2019.
P. Yousefpour, Ahn, L. , Tewksbury, J. , Saha, S. , Costa, S. A. , Bellucci, J. J. , Li, X. , and Chilkoti, A. , Conjugate of Doxorubicin to Albumin‐Binding Peptide Outperforms Aldoxorubicin, Small, vol. 15, no. 12, p. 1804452, 2019.

We are a Duke Green Lab