Chilkoti Group
The Chilkoti group carries out research in two areas: (1) Biomolecular Materials, with a focus on genetically encoded stimulus responsive peptide polymers and fusion proteins for application in protein purification and drug delivery; and (2) Biointerface Science, with a focus on protein-polymer conjugates, the development of low-cost, point-of-care clinical diagnostics, and plasmonic biosensors.
Recent Publications
Controlled Apoptosis by a Thermally Toggled Nanoscale Amplifier of Cellular Uptake. Nano Letters. 14.4 (2014): 2058-2064. Abstract
Enzymatic Polymerization of High Molecular Weight DNA Amphiphiles That Self-Assemble into Star-Like Micelles. Advanced Materials (2014): ASAP. Abstract
“Smart” DNA interfaces. . Vol. 43. Chemical Society Reviews, 43.5., 2014. Abstract
Plasmonic Waveguide Modes of Film-Coupled Metallic Nanocubes. Nano Letters. 13.12 (2013): 5866-5872. Abstract
Growing polymers from peptides and proteins: a biomedical perspective. . Vol. 5. Polymer Chemistry, 5., 2013. Abstract
A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection. Journal of Controlled Release. 172.1 (2013): 144-151. Abstract
Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. . Vol. 29. International Journal of Hyperthermia, 29., 2013. Abstract
Spectroscopic Study of a DNA Brush Synthesized in situ by Surface Initiated Enzymatic Polymerization. The Journal of Physical Chemistry B. 117.34 (2013): 9929-9938. Abstract
Recent News
March 22, 2014:
Congratulations to Jeff and Stacey! They both won service awards from CBTE at Duke, and Jeff also won a poster award. Their awards were presented at the annual CBTE Kewaunee Lecture.
December 9, 2013:
The Chilkoti Labs are now officially Duke Green Labs! We are the first Duke BME lab to go green with our recent Silver award. We are now eyeing that Gold award....
September 30, 2013:
The Chilkoti Group has just returned from a strong showing at the 2013 BMES Annual Meeting. 
Many of our student/postdocs gave talks and presented posters, but perhaps our biggest accomplishment was the fact that Tosh was chosen to deliver the Pritzker Distinguished Lecture, which is the society's most prestigious award. Linked is a summary of the event from BMES. Congrats to Tosh and everyone else who made excellent presentations!
