Chilkoti Group

The Chilkoti group carries out research in two areas: (1) Biomolecular Materials, with a focus on genetically encoded stimulus responsive peptide polymers and fusion proteins for application in protein purification and drug delivery; and (2) Biointerface Science, with a focus on protein-polymer conjugates, the development of low-cost, point-of-care clinical diagnostics, and plasmonic biosensors.

Recent Publications

G. Kelly, Milligan, J. J. , Mastria, E. M. , Kim, S. , Zelenetz, S. R. , Dobbins, J. , Cai, L. Y. , Li, X. , Nair, S. K. , and Chilkoti, A. , Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot, Journal of Controlled Release, vol. 343, pp. 267-276, 2022.
J. T. Heggestad, Kinnamon, D. S. , Olson, L. B. , Liu, J. , Kelly, G. , Wall, S. A. , Oshabaheebwa, S. , Quinn, Z. , Fontes, C. M. , Joh, D. Y. , Hucknall, A. M. , Pieper, C. , Anderson, J. G. , Naqvi, I. A. , Chen, L. , Que, L. G. , Oguin, T. , Nair, S. K. , Sullenger, B. A. , Woods, C. W. , Burke, T. W. , Sempowski, G. D. , Kraft, B. D. , and Chilkoti, A. , Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test, Science Advances, vol. 7, no. 26, p. eabg4901, 2021.
C. M. Fontes, Lipes, B. D. , Liu, J. , Agans, K. N. , Yan, A. , Shi, P. , Cruz, D. F. , Kelly, G. , Luginbuhl, K. M. , Joh, D. Y. , Foster, S. L. , Heggestad, J. , Hucknall, A. , Mikkelsen, M. H. , Pieper, C. F. , Horstmeyer, R. W. , Geisbert, T. W. , Gunn, M. D. , and Chilkoti, A. , Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR, Science Translational Medicine, vol. 13, no. 588, p. eabd9696, 2021.

We are a Duke Green Lab