The Chilkoti group carries out research in two areas: (1) Biomolecular Materials, with a focus on genetically encoded stimulus responsive peptide polymers and fusion proteins for application in protein purification and drug delivery; and (2) Biointerface Science, with a focus on protein-polymer conjugates, the development of low-cost, point-of-care clinical diagnostics, and plasmonic biosensors.
“Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models”, Science Advances, vol. 5674388150261172277237115, no. 9, p. eaaw9162, 2019.,
“Versatile biomanufacturing through stimulus-responsive cell–material feedback”, Nature Chemical Biology, vol. 2532302035683531937414892314536167149194832735283729030981111799511088591151424108270831591597491112174, 2019.,
“Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells”, Molecular Cell, 2019.,