Publications

2023
J. T. Heggestad, Britton, R. J. , Kinnamon, D. S. , Liu, J. , Anderson, J. G. , Joh, D. Y. , Quinn, Z. , Fontes, C. M. , Hucknall, A. M. , Parks, R. , Sempowski, G. D. , Denny, T. N. , Burke, T. W. , Haynes, B. F. , Woods, C. W. , and Chilkoti, A. , “COVID-19 Diagnosis and SARS-CoV-2 Strain Identification by a Rapid, Multiplexed, Point-of-Care Antibody Microarray”, Analytical Chemistry, vol. 95, no. 13, pp. 5610 - 5617, 2023.
D. S. Kinnamon, Heggestad, J. T. , Liu, J. , Nguyen, T. , Ly, V. , Hucknall, A. M. , Fontes, C. M. , Britton, R. J. , Cai, J. - P. , Chan, J. Fuk- Woo, Yuen, K. - Y. , Le, T. , and Chilkoti, A. , “Environmentally Resilient Microfluidic Point-of-Care Immunoassay Enables Rapid Diagnosis of Talaromycosis”, ACS Sensors, 2023.
D. T. Burrow, Heggestad, J. T. , Kinnamon, D. S. , and Chilkoti, A. , “Engineering Innovative Interfaces for Point-of-Care Diagnostics”, Current Opinion in Colloid & Interface Science, p. 101718, 2023.
Y. Dai, Farag, M. , Lee, D. , Zeng, X. , Kim, K. , Son, H. -in, Guo, X. , Su, J. , Peterson, N. , Mohammed, J. , Ney, M. , Shapiro, D. Mark, Pappu, R. V. , Chilkoti, A. , and You, L. , “Programmable synthetic biomolecular condensates for cellular control”, Nature Chemical Biology, 2023.
K. M. Lazar, Shetty, S. , Chilkoti, A. , and Collier, J. H. , “Immune-active polymeric materials for the treatment of inflammatory diseases”, Current Opinion in Colloid & Interface Science, vol. 67, p. 101726, 2023.
Y. Dai, Chamberlayne, C. F. , Messina, M. S. , Chang, C. J. , Zare, R. N. , You, L. , and Chilkoti, A. , “Interface of biomolecular condensates modulates redox reactions”, Chem, vol. 9, no. 6, pp. 1594 - 1609, 2023.
I. Ozer, Slezak, A. , Sirohi, P. , Li, X. , Zakharov, N. , Yao, Y. , Everitt, J. I. , Spasojevic, I. , Craig, S. L. , Collier, J. H. , Campbell, J. E. , D'Alessio, D. A. , and Chilkoti, A. , “An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug”, Biomaterials, vol. 294, p. 121985, 2023.
H. Vahabi, Liu, J. , Dai, Y. , Joh, D. Y. , Britton, R. , Heggestad, J. , Kinnamon, D. , Rajput, S. , and Chilkoti, A. , “A gravity-driven droplet fluidic point-of-care test”, Device, vol. 1, no. 1, p. 100009, 2023.
Y. Dai, You, L. , and Chilkoti, A. , “Engineering synthetic biomolecular condensates”, Nature Reviews Bioengineering, 2023.
2022
L. B. Olson, Hunter, N. I. , Rempel, R. E. , Yu, H. , Spencer, D. M. , Sullenger, C. Z. , Greene, W. S. , Varanko, A. K. , Eghtesadi, S. A. , Chilkoti, A. , Pisetsky, D. S. , Everitt, J. I. , and Sullenger, B. A. , “Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity”, iScience, vol. 25, no. 12, p. 105542, 2022.
J. Haley, Jones, J. B. , Petraki, S. , Callander, M. , Shrestha, S. , Springfield, E. , Adamson, L. , Chilkoti, A. , Dzuricky, M. J. , and Luginbuhl, K. M. , “IsoTag™AAV: an innovative, scalable & non-chromatographic method for streamlined AAV manufacturing”, Cell & Gene Therapy Insights, vol. 8, no. 10, pp. 1287-1300, 2022.
D. Semeniak, Cruz, D. F. , Chilkoti, A. , and Mikkelsen, M. H. , “Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point‐of‐Care: A Review of Recent Technologies”, Advanced Materials, p. 2107986, 2022.
K. H. Lin, Rutter, J. C. , Xie, A. , Killarney, S. T. , Vaganay, C. , Benaksas, C. , Ling, F. , Sodaro, G. , Meslin, P. - A. , Bassil, C. F. , Fenouille, N. , Hoj, J. , Washart, R. , Ang, H. X. , Cerda-Smith, C. , Chaintreuil, P. , Jacquel, A. , Auberger, P. , Forget, A. , Itzykson, R. , Lu, M. , Lin, J. , Pierobon, M. , Sheng, Z. , Li, X. , Chilkoti, A. , Owzar, K. , Rizzieri, D. A. , Pardee, T. S. , Benajiba, L. , Petricoin, E. , Puissant, A. , and Wood, K. C. , “P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia”, Nature Cancer, vol. 3, no. 7, pp. 837 - 851, 2022.
I. Ozer, Pitoc, G. A. , Layzer, J. M. , Moreno, A. , Olson, L. B. , Layzer, K. D. , Hucknall, A. M. , Sullenger, B. A. , and Chilkoti, A. , “PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response”, Advanced Materials, vol. 34, no. 10, p. 2107852, 2022.
I. Ozer, Kelly, G. , Gu, R. , Li, X. , Zakharov, N. , Sirohi, P. , Nair, S. K. , Collier, J. H. , Hershfield, M. S. , Hucknall, A. M. , and Chilkoti, A. , “Polyethylene Glycol‐Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart”, Advanced Science, vol. 9, no. 11, p. 2103672, 2022.
D. S. Kinnamon, Heggestad, J. T. , Liu, J. , and Chilkoti, A. , “Technologies for Frugal and Sensitive Point-of-Care Immunoassays”, Annual Review of Analytical Chemistry, vol. 15, no. 1, pp. 123 - 149, 2022.
J. L. Schaal, Bhattacharyya, J. , Brownstein, J. , Strickland, K. C. , Kelly, G. , Saha, S. , Milligan, J. , Banskota, S. , Li, X. , Liu, W. , Kirsch, D. G. , Zalutsky, M. R. , and Chilkoti, A. , “Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours”, Nature Biomedical Engineering, vol. 6, no. 10, pp. 1148 - 1166, 2022.
C. A. Roden, Dai, Y. , Giannetti, C. A. , Seim, I. , Lee, M. , Sealfon, R. , McLaughlin, G. A. , Boerneke, M. A. , Iserman, C. , Wey, S. A. , Ekena, J. L. , Troyanskaya, O. G. , Weeks, K. M. , You, L. , Chilkoti, A. , and Gladfelter, A. S. , “Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures”, Nucleic Acids Research, vol. 50, no. 14, pp. 8168 - 8192, 2022.
S. Saha, Banskota, S. , Liu, J. , Zakharov, N. , Dzuricky, M. , Li, X. , Fan, P. , Deshpande, S. , Spasojevic, I. , Sharma, K. , Borgnia, M. Juan, Schaal, J. L. , Raman, A. , Kim, S. , Bhattacharyya, J. , and Chilkoti, A. , “Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model”, Nano Letters, vol. 22, no. 14, pp. 5898 - 5908, 2022.
G. Kelly, Milligan, J. J. , Mastria, E. M. , Kim, S. , Zelenetz, S. R. , Dobbins, J. , Cai, L. Y. , Li, X. , Nair, S. K. , and Chilkoti, A. , “Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot”, Journal of Controlled Release, vol. 343, pp. 267-276, 2022.
I. Ozer, Pitoc, G. A. , Layzer, J. M. , Moreno, A. , Olson, L. B. , Layzer, K. D. , Hucknall, A. M. , Sullenger, B. A. , and Chilkoti, A. , “PEG‐like Brush Polymer Conjugate of RNA Aptamer that Shows Reversible Anticoagulant Activity and Minimal Immune Response”, Advanced Materials, p. 2107852, 2022.
2021
C. M. Fontes, Lipes, B. D. , Liu, J. , Agans, K. N. , Yan, A. , Shi, P. , Cruz, D. F. , Kelly, G. , Luginbuhl, K. M. , Joh, D. Y. , Foster, S. L. , Heggestad, J. , Hucknall, A. , Mikkelsen, M. H. , Pieper, C. F. , Horstmeyer, R. W. , Geisbert, T. W. , Gunn, M. D. , and Chilkoti, A. , “Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR”, Science Translational Medicine, vol. 13, no. 588, p. eabd9696, 2021.
X. Zeng, Liu, C. , Fossat, M. J. , Ren, P. , Chilkoti, A. , and Pappu, R. V. , “Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures”, APL Materials, vol. 9, no. 2, p. 021119, 2021.
J. T. Heggestad, Britton, R. J. , Kinnamon, D. S. , Wall, S. A. , Joh, D. Y. , Hucknall, A. M. , Olson, L. B. , Anderson, J. G. , Mazur, A. , Wolfe, C. R. , Oguin, T. H. , Sullenger, B. A. , Burke, T. W. , Kraft, B. D. , Sempowski, G. D. , Woods, C. W. , and Chilkoti, A. , “Rapid test to assess the escape of SARS-CoV-2 variants of concern”, Science Advances, vol. 7, no. 49, 2021.
J. J. Milligan, Saha, S. , Jenkins, I. C. , and Chilkoti, A. , “Genetically encoded elastin-like polypeptide nanoparticles for drug delivery”, Current Opinion in Biotechnology, vol. 74, pp. 146-153, 2021.

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