Publications

2022
J. J. Milligan, Saha, S. , Jenkins, I. C. , and Chilkoti, A. , Genetically encoded elastin-like polypeptide nanoparticles for drug delivery, Current Opinion in Biotechnology, vol. 74, pp. 146-153, 2022.
G. Kelly, Milligan, J. J. , Mastria, E. M. , Kim, S. , Zelenetz, S. R. , Dobbins, J. , Cai, L. Y. , Li, X. , Nair, S. K. , and Chilkoti, A. , Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot, Journal of Controlled Release, vol. 343, pp. 267-276, 2022.
I. Ozer, Pitoc, G. A. , Layzer, J. M. , Moreno, A. , Olson, L. B. , Layzer, K. D. , Hucknall, A. M. , Sullenger, B. A. , and Chilkoti, A. , PEG‐like Brush Polymer Conjugate of RNA Aptamer that Shows Reversible Anticoagulant Activity and Minimal Immune Response, Advanced Materials, p. 2107852, 2022.
2021
C. M. Fontes, Lipes, B. D. , Liu, J. , Agans, K. N. , Yan, A. , Shi, P. , Cruz, D. F. , Kelly, G. , Luginbuhl, K. M. , Joh, D. Y. , Foster, S. L. , Heggestad, J. , Hucknall, A. , Mikkelsen, M. H. , Pieper, C. F. , Horstmeyer, R. W. , Geisbert, T. W. , Gunn, M. D. , and Chilkoti, A. , Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR, Science Translational Medicine, vol. 13, no. 588, p. eabd9696, 2021.
X. Zeng, Liu, C. , Fossat, M. J. , Ren, P. , Chilkoti, A. , and Pappu, R. V. , Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures, APL Materials, vol. 9, no. 2, p. 021119, 2021.
J. T. Heggestad, Britton, R. J. , Kinnamon, D. S. , Wall, S. A. , Joh, D. Y. , Hucknall, A. M. , Olson, L. B. , Anderson, J. G. , Mazur, A. , Wolfe, C. R. , Oguin, T. H. , Sullenger, B. A. , Burke, T. W. , Kraft, B. D. , Sempowski, G. D. , Woods, C. W. , and Chilkoti, A. , Rapid test to assess the escape of SARS-CoV-2 variants of concern, Science Advances, vol. 7, no. 49, 2021.
P. Weber, Dzuricky, M. , Min, J. , Jenkins, I. , and Chilkoti, A. , Concentration-Independent Multivalent Targeting of Cancer Cells by Genetically Encoded Core-Crosslinked Elastin/Resilin-like Polypeptide Micelles, Biomacromolecules, vol. 22, no. 10, pp. 4347 - 4356, 2021.
L. A. Navarro, Ryan, J. J. , Dzuricky, M. , Gradzielski, M. , Chilkoti, A. , and Zauscher, S. , Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions, Biomacromolecules, vol. 22, no. 9, pp. 3827 - 3838, 2021.
D. Y. Joh, Heggestad, J. T. , Zhang, S. , Anderson, G. R. , Bhattacharyya, J. , Wardell, S. E. , Wall, S. A. , Cheng, A. B. , Albarghouthi, F. , Liu, J. , Oshima, S. , Hucknall, A. M. , Hyslop, T. , Hall, A. H. S. , Wood, K. C. , E. Hwang, S. , Strickland, K. C. , Wei, Q. , and Chilkoti, A. , Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates, npj Breast Cancer, vol. 7, no. 1, 2021.
J. T. Heggestad, Kinnamon, D. S. , Olson, L. B. , Liu, J. , Kelly, G. , Wall, S. A. , Oshabaheebwa, S. , Quinn, Z. , Fontes, C. M. , Joh, D. Y. , Hucknall, A. M. , Pieper, C. , Anderson, J. G. , Naqvi, I. A. , Chen, L. , Que, L. G. , Oguin, T. , Nair, S. K. , Sullenger, B. A. , Woods, C. W. , Burke, T. W. , Sempowski, G. D. , Kraft, B. D. , and Chilkoti, A. , Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test, Science Advances, vol. 7, no. 26, p. eabg4901, 2021.
D. Mark Shapiro, Ney, M. , Eghtesadi, S. Ali, and Chilkoti, A. , Protein Phase Separation Arising from Intrinsic Disorder: First-Principles to Bespoke Applications, The Journal of Physical Chemistry B, vol. 125, no. 25, pp. 6740 - 6759, 2021.
I. C. Jenkins, Milligan, J. J. , and Chilkoti, A. , Genetically Encoded Elastin‐Like Polypeptides for Drug Delivery, Advanced Healthcare Materials, vol. 10, no. 13, p. 2100209, 2021.
K. M. Hainline, Shores, L. S. , Votaw, N. L. , Bernstein, Z. J. , Kelly, S. H. , Fries, C. N. , Madhira, M. S. , Gilroy, C. A. , Chilkoti, A. , and Collier, J. H. , Modular complement assemblies for mitigating inflammatory conditions, Proceedings of the National Academy of Sciences, vol. 118, no. 15, p. e2018627118, 2021.
K. Laaß, Quiroz, F. G. , Hunold, J. , Roberts, S. , Chilkoti, A. , and Hinderberger, D. , Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins, Biomacromolecules, vol. 22, no. 2, pp. 1015 - 1025, 2021.
J. T. Heggestad, Kinnamon, D. S. , Liu, J. , Joh, D. Y. , Fontes, C. M. , Wei, Q. , Ozcan, A. , Hucknall, A. M. , and Chilkoti, A. , Methods in Molecular BiologyBiomedical Engineering TechnologiesSmartphone Enabled Point-of-Care Detection of Serum Biomarkers, vol. 2393. New York, NY: Springer US, 2021, pp. 343 - 365.
2020
M. Dzuricky, Rogers, B. A. , Shahid, A. , Cremer, P. S. , and Chilkoti, A. , De novo engineering of intracellular condensates using artificial disordered proteins, Nature Chemistry, 2020.
J. Wang, Min, J. , Eghtesadi, S. Ali, Kane, R. S. , and Chilkoti, A. , A Quantitative Study of the Interaction of Multivalent Ligand-Modified Nanoparticles with Breast Cancer Cells with Tunable Receptor Density, ACS Nano, 2020.
C. A. Gilroy, Capozzi, M. E. , Varanko, A. K. , Tong, J. , D'Alessio, D. A. , Campbell, J. E. , and Chilkoti, A. , Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia, Science Advances, vol. 6, no. 35, p. eaaz9890, 2020.
A. K. Varanko, Su, J. C. , and Chilkoti, A. , Elastin-Like Polypeptides for Biomedical Applications, Annual Review of Biomedical Engineering, vol. 22, no. 1, pp. 343 - 369, 2020.
S. Saha, Banskota, S. , Roberts, S. , Kirmani, N. , and Chilkoti, A. , Engineering the Architecture of Elastin‐Like Polypeptides: From Unimers to Hierarchical Self‐Assembly, Advanced Therapeutics, vol. 3, no. 3, 2020.
A. Varanko, Saha, S. , and Chilkoti, A. , Recent trends in protein and peptide-based biomaterials for advanced drug delivery., Adv Drug Deliv Rev, vol. 156, pp. 133-187, 2020.
J. T. Heggestad, Fontes, C. M. , Joh, D. Y. , Hucknall, A. M. , and Chilkoti, A. , In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays, Advanced Materials, vol. 32, no. 2, p. 1903285, 2020.
L. Li, C. Shields, W. , Huang, J. , Zhang, Y. , Ohiri, K. A. , Yellen, B. B. , Chilkoti, A. , and López, G. P. , Rapid capture of biomolecules from blood via stimuli-responsive elastomeric particles for acoustofluidic separation, The Analyst, vol. 145, no. 24, pp. 8087 - 8096, 2020.
P. Yousefpour, Varanko, A. , Subrahmanyan, R. , and Chilkoti, A. , Recombinant Fusion of Glucagon‐Like Peptide‐1 and an Albumin Binding Domain Provides Glycemic Control for a Week in Diabetic Mice, Advanced Therapeutics, vol. 3, no. 10, p. 2000073, 2020.
S. Roberts, Miao, V. , Costa, S. , Simon, J. , Kelly, G. , Shah, T. , Zauscher, S. , and Chilkoti, A. , Complex microparticle architectures from stimuli-responsive intrinsically disordered proteins, Nature Communications, vol. 11, no. 1342, 2020.

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