Publications

2023
Y. Dai, Farag, M. , Lee, D. , Zeng, X. , Kim, K. , Son, H. -in, Guo, X. , Su, J. , Peterson, N. , Mohammed, J. , Ney, M. , Shapiro, D. Mark, Pappu, R. V. , Chilkoti, A. , and You, L. , “Programmable synthetic biomolecular condensates for cellular control”, Nature Chemical Biology, 2023.
2022
L. B. Olson, Hunter, N. I. , Rempel, R. E. , Yu, H. , Spencer, D. M. , Sullenger, C. Z. , Greene, W. S. , Varanko, A. K. , Eghtesadi, S. A. , Chilkoti, A. , Pisetsky, D. S. , Everitt, J. I. , and Sullenger, B. A. , “Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity”, iScience, vol. 25, no. 12, p. 105542, 2022.
J. Haley, Jones, J. B. , Petraki, S. , Callander, M. , Shrestha, S. , Springfield, E. , Adamson, L. , Chilkoti, A. , Dzuricky, M. J. , and Luginbuhl, K. M. , “IsoTag™AAV: an innovative, scalable & non-chromatographic method for streamlined AAV manufacturing”, Cell & Gene Therapy Insights, vol. 8, no. 10, pp. 1287-1300, 2022.
D. Semeniak, Cruz, D. F. , Chilkoti, A. , and Mikkelsen, M. H. , “Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point‐of‐Care: A Review of Recent Technologies”, Advanced Materials, p. 2107986, 2022.
K. H. Lin, Rutter, J. C. , Xie, A. , Killarney, S. T. , Vaganay, C. , Benaksas, C. , Ling, F. , Sodaro, G. , Meslin, P. - A. , Bassil, C. F. , Fenouille, N. , Hoj, J. , Washart, R. , Ang, H. X. , Cerda-Smith, C. , Chaintreuil, P. , Jacquel, A. , Auberger, P. , Forget, A. , Itzykson, R. , Lu, M. , Lin, J. , Pierobon, M. , Sheng, Z. , Li, X. , Chilkoti, A. , Owzar, K. , Rizzieri, D. A. , Pardee, T. S. , Benajiba, L. , Petricoin, E. , Puissant, A. , and Wood, K. C. , “P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia”, Nature Cancer, vol. 3, no. 7, pp. 837 - 851, 2022.
I. Ozer, Pitoc, G. A. , Layzer, J. M. , Moreno, A. , Olson, L. B. , Layzer, K. D. , Hucknall, A. M. , Sullenger, B. A. , and Chilkoti, A. , “PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response”, Advanced Materials, vol. 34, no. 10, p. 2107852, 2022.
I. Ozer, Kelly, G. , Gu, R. , Li, X. , Zakharov, N. , Sirohi, P. , Nair, S. K. , Collier, J. H. , Hershfield, M. S. , Hucknall, A. M. , and Chilkoti, A. , “Polyethylene Glycol‐Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart”, Advanced Science, vol. 9, no. 11, p. 2103672, 2022.
D. S. Kinnamon, Heggestad, J. T. , Liu, J. , and Chilkoti, A. , “Technologies for Frugal and Sensitive Point-of-Care Immunoassays”, Annual Review of Analytical Chemistry, vol. 15, no. 1, pp. 123 - 149, 2022.
J. L. Schaal, Bhattacharyya, J. , Brownstein, J. , Strickland, K. C. , Kelly, G. , Saha, S. , Milligan, J. , Banskota, S. , Li, X. , Liu, W. , Kirsch, D. G. , Zalutsky, M. R. , and Chilkoti, A. , “Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours”, Nature Biomedical Engineering, vol. 6, no. 10, pp. 1148 - 1166, 2022.
C. A. Roden, Dai, Y. , Giannetti, C. A. , Seim, I. , Lee, M. , Sealfon, R. , McLaughlin, G. A. , Boerneke, M. A. , Iserman, C. , Wey, S. A. , Ekena, J. L. , Troyanskaya, O. G. , Weeks, K. M. , You, L. , Chilkoti, A. , and Gladfelter, A. S. , “Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures”, Nucleic Acids Research, vol. 50, no. 14, pp. 8168 - 8192, 2022.
S. Saha, Banskota, S. , Liu, J. , Zakharov, N. , Dzuricky, M. , Li, X. , Fan, P. , Deshpande, S. , Spasojevic, I. , Sharma, K. , Borgnia, M. Juan, Schaal, J. L. , Raman, A. , Kim, S. , Bhattacharyya, J. , and Chilkoti, A. , “Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model”, Nano Letters, vol. 22, no. 14, pp. 5898 - 5908, 2022.
G. Kelly, Milligan, J. J. , Mastria, E. M. , Kim, S. , Zelenetz, S. R. , Dobbins, J. , Cai, L. Y. , Li, X. , Nair, S. K. , and Chilkoti, A. , “Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot”, Journal of Controlled Release, vol. 343, pp. 267-276, 2022.
I. Ozer, Pitoc, G. A. , Layzer, J. M. , Moreno, A. , Olson, L. B. , Layzer, K. D. , Hucknall, A. M. , Sullenger, B. A. , and Chilkoti, A. , “PEG‐like Brush Polymer Conjugate of RNA Aptamer that Shows Reversible Anticoagulant Activity and Minimal Immune Response”, Advanced Materials, p. 2107852, 2022.
2021
C. M. Fontes, Lipes, B. D. , Liu, J. , Agans, K. N. , Yan, A. , Shi, P. , Cruz, D. F. , Kelly, G. , Luginbuhl, K. M. , Joh, D. Y. , Foster, S. L. , Heggestad, J. , Hucknall, A. , Mikkelsen, M. H. , Pieper, C. F. , Horstmeyer, R. W. , Geisbert, T. W. , Gunn, M. D. , and Chilkoti, A. , “Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR”, Science Translational Medicine, vol. 13, no. 588, p. eabd9696, 2021.
X. Zeng, Liu, C. , Fossat, M. J. , Ren, P. , Chilkoti, A. , and Pappu, R. V. , “Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures”, APL Materials, vol. 9, no. 2, p. 021119, 2021.
J. T. Heggestad, Britton, R. J. , Kinnamon, D. S. , Wall, S. A. , Joh, D. Y. , Hucknall, A. M. , Olson, L. B. , Anderson, J. G. , Mazur, A. , Wolfe, C. R. , Oguin, T. H. , Sullenger, B. A. , Burke, T. W. , Kraft, B. D. , Sempowski, G. D. , Woods, C. W. , and Chilkoti, A. , “Rapid test to assess the escape of SARS-CoV-2 variants of concern”, Science Advances, vol. 7, no. 49, 2021.
J. J. Milligan, Saha, S. , Jenkins, I. C. , and Chilkoti, A. , “Genetically encoded elastin-like polypeptide nanoparticles for drug delivery”, Current Opinion in Biotechnology, vol. 74, pp. 146-153, 2021.
P. Weber, Dzuricky, M. , Min, J. , Jenkins, I. , and Chilkoti, A. , “Concentration-Independent Multivalent Targeting of Cancer Cells by Genetically Encoded Core-Crosslinked Elastin/Resilin-like Polypeptide Micelles”, Biomacromolecules, vol. 22, no. 10, pp. 4347 - 4356, 2021.
L. A. Navarro, Ryan, J. J. , Dzuricky, M. , Gradzielski, M. , Chilkoti, A. , and Zauscher, S. , “Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions”, Biomacromolecules, vol. 22, no. 9, pp. 3827 - 3838, 2021.
D. Y. Joh, Heggestad, J. T. , Zhang, S. , Anderson, G. R. , Bhattacharyya, J. , Wardell, S. E. , Wall, S. A. , Cheng, A. B. , Albarghouthi, F. , Liu, J. , Oshima, S. , Hucknall, A. M. , Hyslop, T. , Hall, A. H. S. , Wood, K. C. , E. Hwang, S. , Strickland, K. C. , Wei, Q. , and Chilkoti, A. , “Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates”, npj Breast Cancer, vol. 7, no. 1, 2021.
J. T. Heggestad, Kinnamon, D. S. , Olson, L. B. , Liu, J. , Kelly, G. , Wall, S. A. , Oshabaheebwa, S. , Quinn, Z. , Fontes, C. M. , Joh, D. Y. , Hucknall, A. M. , Pieper, C. , Anderson, J. G. , Naqvi, I. A. , Chen, L. , Que, L. G. , Oguin, T. , Nair, S. K. , Sullenger, B. A. , Woods, C. W. , Burke, T. W. , Sempowski, G. D. , Kraft, B. D. , and Chilkoti, A. , “Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test”, Science Advances, vol. 7, no. 26, p. eabg4901, 2021.
D. Mark Shapiro, Ney, M. , Eghtesadi, S. Ali, and Chilkoti, A. , “Protein Phase Separation Arising from Intrinsic Disorder: First-Principles to Bespoke Applications”, The Journal of Physical Chemistry B, vol. 125, no. 25, pp. 6740 - 6759, 2021.
I. C. Jenkins, Milligan, J. J. , and Chilkoti, A. , “Genetically Encoded Elastin‐Like Polypeptides for Drug Delivery”, Advanced Healthcare Materials, vol. 10, no. 13, p. 2100209, 2021.
K. M. Hainline, Shores, L. S. , Votaw, N. L. , Bernstein, Z. J. , Kelly, S. H. , Fries, C. N. , Madhira, M. S. , Gilroy, C. A. , Chilkoti, A. , and Collier, J. H. , “Modular complement assemblies for mitigating inflammatory conditions”, Proceedings of the National Academy of Sciences, vol. 118, no. 15, p. e2018627118, 2021.
K. Laaß, Quiroz, F. G. , Hunold, J. , Roberts, S. , Chilkoti, A. , and Hinderberger, D. , “Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins”, Biomacromolecules, vol. 22, no. 2, pp. 1015 - 1025, 2021.

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