Therapeutic agents comprising elastin-like peptides

TitleTherapeutic agents comprising elastin-like peptides
Publication TypePatent
Year of Publication2020
AuthorsChilkoti, A
Patent Version NumberUS20200282022A1
International Patent NumberUS20200282022A1
International Patent ClassificationA61K38/28
Application NumberUS20200282022A1
Date Published09/2020
Abstract

The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.