Unstructured non-repetitive polypeptides having LCST behavior

TitleUnstructured non-repetitive polypeptides having LCST behavior
Publication TypePatent
Year of Publication2021
AuthorsChilkoti, A, Tang, N, Kelly, G
Date Published10/26/2021
AssigneeDuke University
Patent TypeGrant
Patent Number11155584

Described herein are unstructured polypeptides lacking any discernible repeat motif. Also described herein are fusion proteins including at least one of the unstructured polypeptides and at least one binding polypeptide. Further described are methods for treating a disease in a subject in need thereof. The methods may include administering to the subject an effective amount of the fusion protein.