Chilkoti Group

The Chilkoti group carries out research in two areas: (1) Biomolecular Materials, with a focus on genetically encoded stimulus responsive peptide polymers and fusion proteins for application in protein purification and drug delivery; and (2) Biointerface Science, with a focus on protein-polymer conjugates, the development of low-cost, point-of-care clinical diagnostics, and plasmonic biosensors.

Recent Publications

C. M. Fontes, Lipes, B. D. , Liu, J. , Agans, K. N. , Yan, A. , Shi, P. , Cruz, D. F. , Kelly, G. , Luginbuhl, K. M. , Joh, D. Y. , Foster, S. L. , Heggestad, J. , Hucknall, A. , Mikkelsen, M. H. , Pieper, C. F. , Horstmeyer, R. W. , Geisbert, T. W. , Gunn, M. D. , and Chilkoti, A. , Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR, Science Translational Medicine, vol. 13, no. 588, p. eabd9696, 2021.
M. Dzuricky, Rogers, B. A. , Shahid, A. , Cremer, P. S. , and Chilkoti, A. , De novo engineering of intracellular condensates using artificial disordered proteins, Nature Chemistry, 2020.
S. Roberts, Miao, V. , Costa, S. , Simon, J. , Kelly, G. , Shah, T. , Zauscher, S. , and Chilkoti, A. , Complex microparticle architectures from stimuli-responsive intrinsically disordered proteins, Nature Communications, vol. 11, no. 1342, 2020.

We are a Duke Green Lab