Chilkoti Group

The Chilkoti group carries out research in two areas: (1) Biomolecular Materials, with a focus on genetically encoded stimulus responsive peptide polymers and fusion proteins for application in protein purification and drug delivery; and (2) Biointerface Science, with a focus on protein-polymer conjugates, the development of low-cost, point-of-care clinical diagnostics, and plasmonic biosensors.

Recent Publications

F. Garcia Quiroz, Li, N. K. , Roberts, S. , Weber, P. , Dzuricky, M. , Weitzhandler, I. , Yingling, Y. G. , and Chilkoti, A. , Intrinsically disordered proteins access a range of hysteretic phase separation behaviors, Science Advances, vol. 5173193363355141541046164516151063419184550218545550, no. 10, p. eaax5177, 2019.
M. T. Manzari, Anderson, G. R. , Lin, K. H. , Soderquist, R. S. , Çakir, M. , Zhang, M. , Moore, C. E. , Skelton, R. N. , èvre, éva, Li, X. , Bellucci, J. J. , Wardell, S. E. , Costa, S. A. , Wood, K. C. , and Chilkoti, A. , Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models, Science Advances, vol. 5, no. 9, p. eaaw9162, 2019.
Z. Dai, Lee, A. J. , Roberts, S. , Sysoeva, T. A. , Huang, S. , Dzuricky, M. , Yang, X. , Zhang, X. , Liu, Z. , Chilkoti, A. , and You, L. , Versatile biomanufacturing through stimulus-responsive cell–material feedback, Nature Chemical Biology, vol. 15, 2019.

We are a Duke Green Lab