Chilkoti Group

The Chilkoti group carries out research in two areas: (1) Biomolecular Materials, with a focus on genetically encoded stimulus responsive peptide polymers and fusion proteins for application in protein purification and drug delivery; and (2) Biointerface Science, with a focus on protein-polymer conjugates, the development of low-cost, point-of-care clinical diagnostics, and plasmonic biosensors.

Recent Publications

D. Mozhdehi, Luginbuhl, K. M. , Simon, J. R. , Dzuricky, M. , Berger, üdiger, H. Varol, S. , Huang, F. C. , Buehne, K. L. , Mayne, N. R. , Weitzhandler, I. , Bonn, M. , Parekh, S. H. , and Chilkoti, A. , “Genetically encoded lipid–polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly”, Nature Chemistry, vol. 428, 2018.
C. A. Gilroy, Roberts, S. , and Chilkoti, A. , “Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action”, Journal of Controlled Release, 2018.
S. A. Costa, Simon, J. R. , Amiram, M. , Tang, L. , Zauscher, S. , Brustad, E. M. , Isaacs, F. J. , and Chilkoti, A. , “Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides”, Advanced Materials, vol. 1521-4095, p. 1704878, 2017.

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