Publications

Shapiro, Daniel Mark, Sonal Deshpande, Seyed Ali Eghtesadi, Miranda Zhong, Cassio Mendes Fontes, David Fiflis, Dahlia Rohm, et al. “Synthetic biomolecular condensates enhance translation from a target mRNA in living cells.” Nat Chem 17, no. 3 (March 2025): 448–56. https://doi.org/10.1038/s41557-024-01706-7.

Shapiro, Daniel Mark., Sonal Deshpande, Seyed Ali Eghtesadi, Miranda Zhong, Cassio Mendes Fontes, David Fiflis, Dahlia Rohm, Junseon Min, Taranpreet Kaur, Joanna Peng, Max Ney, Jonathan Su, Yifan Dai, Aravind Asokan, Charles A. Gersbach, Ashutosh Chilkoti. "Synthetic biomolecular condensates enhance translation from a target mRNA in living cells", Nature Chemistry, February 10, 2025. https://doi.org/10.1038/s41557-024-01706-7

Varanko, Anastasia K., Sonal Deshpande, Xinghai Li, and Ashutosh Chilkoti. “Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors.” Biomacromolecules 26, no. 1 (January 2025): 503–13. https://doi.org/10.1021/acs.biomac.4c01303.

Varanko, Anastasia K., Sonal Deshpande, Xinghai Li, and Ashutosh Chilkoti. "Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors." Biomacromolecules 26, no. 1 (2024), December 27, 2024. https://pubs.acs.org/doi/full/10.1021/acs.biomac.4c01303.

‌

Saha, S., S. Banskota, P. Yousefpour, J. L. Schaal, N. Zakharov, J. Liu, M. Dzuricky, et al. “Preclinical Development of a Genetically Engineered Albumin-Binding Nanoparticle of Paclitaxel.” Small Science 4, no. 11 (November 1, 2024). https://doi.org/10.1002/smsc.202400153.

Dai, Yifan, Zhengqing Zhou, Wen Yu, Yuefeng Ma, Kyeri Kim, Nelson Rivera, Javid Mohammed, et al. “Biomolecular condensates regulate cellular electrochemical equilibria.” Cell, September 2024, S0092-8674(24)00909-7. https://doi.org/10.1016/j.cell.2024.08.018.

Stormo, Benjamin M., Grace A. McLaughlin, Ameya P. Jalihal, Logan K. Frederick, Sierra J. Cole, Ian Seim, Fred S. Dietrich, Ashutosh Chilkoti, and Amy S. Gladfelter. “Intrinsically disordered sequences can tune fungal growth and the cell cycle for specific temperatures.” Curr Biol 34, no. 16 (August 19, 2024): 3722-3734.e7. https://doi.org/10.1016/j.cub.2024.07.015.

Tang, Nicholas C., Jonathan C. Su, Yulia Shmidov, Garrett Kelly, Sonal Deshpande, Parul Sirohi, Nikhil Peterson, and Ashutosh Chilkoti. “Synthetic intrinsically disordered protein fusion tags that enhance protein solubility.” Nature Communications 15, no. 1 (May 2024): 3727. https://doi.org/10.1038/s41467-024-47519-7.

Li, Zongru, Qionghua Shen, Emery T. Usher, Andrew P. Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, et al. “Phase transition of GvpU regulates gas vesicle clustering in bacteria.” Nature Microbiology 9, no. 4 (April 2024): 1021–35. https://doi.org/10.1038/s41564-024-01648-3.

Walter, Vivien, Tatiana Schmatko, Pierre Muller, André P. Schroder, Sarah R. MacEwan, Ashutosh Chilkoti, and Carlos M. Marques. “Negative lipid membranes enhance the adsorption of TAT-decorated elastin-like polypeptide micelles.” Biophysical Journal 123, no. 7 (April 2024): 901–8. https://doi.org/10.1016/j.bpj.2024.03.001.

Albarghouthi, Faris M., Daria Semeniak, Iman Khanani, James L. Doherty, Brittany N. Smith, Matthew Salfity, Quentin MacFarlane, et al. “Addressing Signal Drift and Screening for Detection of Biomarkers with Carbon Nanotube Transistors.” ACS Nano, February 2024. https://doi.org/10.1021/acsnano.3c11679.

Strader, Rachel L., Yulia Shmidov, and Ashutosh Chilkoti. “Encoding Structure in Intrinsically Disordered Protein Biomaterials.” Accounts of Chemical Research 57, no. 3 (February 2024): 302–11. https://doi.org/10.1021/acs.accounts.3c00624.

Deshpande, Sonal, Yunqi Yang, Stefan Zauscher, and Ashutosh Chilkoti. “Enzymatic Synthesis of Aptamer-Polynucleotide Nanoparticles with High Anticancer Drug Loading for Targeted Delivery.” Biomacromolecules 25, no. 1 (January 2024): 155–64. https://doi.org/10.1021/acs.biomac.3c00888.

Subramaniam, Shankar, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, et al. “Grand Challenges at the Interface of Engineering and Medicine.” IEEE Open J Eng Med Biol 5 (2024): 1–13. https://doi.org/10.1109/OJEMB.2024.3351717.

Sethi, Vaishali, Dana Cohen-Gerassi, Sagi Meir, Max Ney, Yulia Shmidov, Gil Koren, Lihi Adler-Abramovich, Ashutosh Chilkoti, and Roy Beck. “Modulating hierarchical self-assembly in thermoresponsive intrinsically disordered proteins through high-temperature incubation time.” Scientific Reports 13, no. 1 (December 2023): 21688. https://doi.org/10.1038/s41598-023-48483-w.

Lazar, K. M., S. Shetty, A. Chilkoti, and J. H. Collier. “Immune-active polymeric materials for the treatment of inflammatory diseases.” Current Opinion in Colloid and Interface Science 67 (October 1, 2023). https://doi.org/10.1016/j.cocis.2023.101726.

Semeniak, Daria, Daniela F. Cruz, Ashutosh Chilkoti, and Maiken H. Mikkelsen. “Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.” Advanced Materials (Deerfield Beach, Fla.) 35, no. 34 (August 2023): e2107986. https://doi.org/10.1002/adma.202107986.

Vahabi, Hamed, Jason Liu, Yifan Dai, Daniel Y. Joh, Rhett Britton, Jacob Heggestad, David Kinnamon, Satyam Rajput, and Ashutosh Chilkoti. “A gravity-driven droplet fluidic point-of-care test.” Device 1, no. 1 (July 2023): 100009. https://doi.org/10.1016/j.device.2023.100009.

Kinnamon, David S., Jacob T. Heggestad, Jason Liu, Thu Nguyen, Vo Ly, Angus M. Hucknall, Cassio M. Fontes, et al. “Environmentally Resilient Microfluidic Point-of-Care Immunoassay Enables Rapid Diagnosis of Talaromycosis.” ACS Sens 8, no. 6 (June 23, 2023): 2228–36. https://doi.org/10.1021/acssensors.3c00209.

Burrow, Damon T., Jacob T. Heggestad, David S. Kinnamon, and Ashutosh Chilkoti. “Engineering Innovative Interfaces for Point-of-Care Diagnostics.” Current Opinion in Colloid & Interface Science, June 2023, 101718. https://doi.org/10.1016/j.cocis.2023.101718.

Dai, Yifan, Christian F. Chamberlayne, Marco S. Messina, Christopher J. Chang, Richard N. Zare, Lingchong You, and Ashutosh Chilkoti. “Interface of biomolecular condensates modulates redox reactions.” Chem 9, no. 6 (June 2023): 1594–1609. https://doi.org/10.1016/j.chempr.2023.04.001.

Heggestad, Jacob T., Rhett J. Britton, David S. Kinnamon, Jason Liu, Jack G. Anderson, Daniel Y. Joh, Zachary Quinn, et al. “COVID-19 Diagnosis and SARS-CoV-2 Strain Identification by a Rapid, Multiplexed, Point-of-Care Antibody Microarray.” Anal Chem 95, no. 13 (April 4, 2023): 5610–17. https://doi.org/10.1021/acs.analchem.2c05180.

Dai, Yifan, Mina Farag, Dongheon Lee, Xiangze Zeng, Kyeri Kim, Hye-In Son, Xiao Guo, et al. “Programmable synthetic biomolecular condensates for cellular control.” Nature Chemical Biology 19, no. 4 (April 2023): 518–28. https://doi.org/10.1038/s41589-022-01252-8.

Dai, Yifan, Lingchong You, and Ashutosh Chilkoti. “Engineering synthetic biomolecular condensates.” Nature Reviews Bioengineering, April 2023, 1–15. https://doi.org/10.1038/s44222-023-00052-6.

Y. Dai, You, L. , and Chilkoti, A. , “Engineering synthetic biomolecular condensates”, Nature Reviews Bioengineering, 2023.