Publications

Kim, Sarah Yeon-Kyoung, Taranpreet Kaur, Yulia Shmidov, Matthew Yiren Wang, Lixin Fan, Abigail Leo, Nicolas Angustia, Yan Xiang, Daniel Reker, and Ashutosh Chilkoti. “Genetically Encoded Sterol-Modification of a Synthetic Intrinsically Disordered Protein Drives Its Self-Assembly Into Diverse Morphologies.” Small (Weinheim an Der Bergstrasse, Germany), February 2026, e09658. https://doi.org/10.1002/smll.202509658.

Sirohi, Parul, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis et al. "All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery." Advanced Science (2026): e17048.

Sirohi, Parul, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, et al. “All-PEG-Like Block Copolymers Self-Assemble into Stealth Nanocarriers for Drug Delivery.” Advanced Science (Weinheim, Baden-Wurttemberg, Germany), January 2026, e17048. https://doi.org/10.1002/advs.202517048.

Milligan, Joshua J., Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, et al. “Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer.” Adv Sci (Weinh) 12, no. 37 (October 2025): e03591. https://doi.org/10.1002/advs.202503591.

Quintana, Adam, Linying Li, Ashutosh Chilkoti, Gabriel P. López, and Nick J. Carroll. “Rational Design of Thermoresponsive Elastin-Like Protein Monolayers for Nonenzymatic Cell Harvesting.” Biomacromolecules 26, no. 9 (September 2025): 5958–64. https://doi.org/10.1021/acs.biomac.5c00861.

Su, J. C., G. M. Kelly, J. J. Milligan, S. Deshpande, R. L. Strader, M. R. Ney, N. Peterson, et al. “Spatiotemporal Control of IL-12 Delivery Improves Its Efficacy in Treatment of Solid Tumors.” Advanced Therapeutics 8, no. 8 (August 1, 2025). https://doi.org/10.1002/adtp.202500077.

Ata, Hirotaka, Madeleine E. Hull, William M. Geisler, Sixto M. Leal, and Ashutosh Chilkoti. “Rapid, Amplification-free, RNA-based Uropathogen Detection With LbuCas13a.” Open Forum Infectious Diseases 12, no. 8 (August 2025): ofaf477. https://doi.org/10.1093/ofid/ofaf477.

Zheng, Chuanbao, Yulia Shmidov, Anastasia K. Varanko, Sonal Deshpande, Yunqi Yang, Daniel M. Shapiro, Zhisen Zhang, Han Zuilhof, Ashutosh Chilkoti, and Renko de Vries. “Nonfouling Coatings from Synthetic Intrinsically Disordered Proteins.” Small (Weinheim an Der Bergstrasse, Germany) 21, no. 34 (August 2025): e2504365. https://doi.org/10.1002/smll.202504365.

Mallory, Micah, Emma Grace Johnson, Soumen Saha, Sanika Pandit, Joshua T. McCune, Mengnan Dennis, Jessica M. Gluck, et al. “From saccharides to synthetics: exploring biomaterial scaffolds as cell transduction enhancers.” Biomaterials Science 13, no. 13 (June 2025): 3585–97. https://doi.org/10.1039/d4bm01588f.

Putman, Rachael, Neill Li, Daniel Y. Joh, Stefan Roberts, Tyler Pidgeon, Suhail Mithani, and Ashutosh Chilkoti. “Designing Next-Generation Biomaterials to Enhance Peripheral Nerve Repair and Reconstruction.” J Biomed Mater Res A 113, no. 6 (June 2025): e37930. https://doi.org/10.1002/jbm.a.37930.

Shapiro, Daniel Mark, Sonal Deshpande, Seyed Ali Eghtesadi, Miranda Zhong, Cassio Mendes Fontes, David Fiflis, Dahlia Rohm, et al. “Synthetic biomolecular condensates enhance translation from a target mRNA in living cells.” Nat Chem 17, no. 3 (March 2025): 448–56. https://doi.org/10.1038/s41557-024-01706-7.

Shapiro, Daniel Mark., Sonal Deshpande, Seyed Ali Eghtesadi, Miranda Zhong, Cassio Mendes Fontes, David Fiflis, Dahlia Rohm, Junseon Min, Taranpreet Kaur, Joanna Peng, Max Ney, Jonathan Su, Yifan Dai, Aravind Asokan, Charles A. Gersbach, Ashutosh Chilkoti. "Synthetic biomolecular condensates enhance translation from a target mRNA in living cells", Nature Chemistry, February 10, 2025. https://doi.org/10.1038/s41557-024-01706-7

Varanko, Anastasia K., Sonal Deshpande, Xinghai Li, and Ashutosh Chilkoti. “Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors.” Biomacromolecules 26, no. 1 (January 2025): 503–13. https://doi.org/10.1021/acs.biomac.4c01303.

Varanko, Anastasia K., Sonal Deshpande, Xinghai Li, and Ashutosh Chilkoti. "Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors." Biomacromolecules 26, no. 1 (2024), December 27, 2024. https://pubs.acs.org/doi/full/10.1021/acs.biomac.4c01303.

Saha, Soumen, Samagya Banskota, Parisa Yousefpour, Jeffrey L. Schaal, Nikita Zakharov, Jianqiao Liu, Michael Dzuricky, et al. “Preclinical Development of a Genetically Engineered Albumin-Binding Nanoparticle of Paclitaxel.” Small Science 4, no. 11 (November 2024): 2400153. https://doi.org/10.1002/smsc.202400153.

Lee, Dongheon, Yifan Dai, Hye-In Son, Kyeri Kim, Ashutosh Chilkoti, and Lingchong You. "Biomolecular Phase Separation Suppresses Gene Expression in Bacteria." In 2024 AIChE Annual Meeting. AIChE, 2024.

Dai, Yifan, Zhengqing Zhou, Wen Yu, Yuefeng Ma, Kyeri Kim, Nelson Rivera, Javid Mohammed, et al. “Biomolecular condensates regulate cellular electrochemical equilibria.” Cell 187, no. 21 (October 2024): 5951-5966.e18. https://doi.org/10.1016/j.cell.2024.08.018.

Stormo, Benjamin M., Grace A. McLaughlin, Ameya P. Jalihal, Logan K. Frederick, Sierra J. Cole, Ian Seim, Fred S. Dietrich, Ashutosh Chilkoti, and Amy S. Gladfelter. “Intrinsically disordered sequences can tune fungal growth and the cell cycle for specific temperatures.” Curr Biol 34, no. 16 (August 19, 2024): 3722-3734.e7. https://doi.org/10.1016/j.cub.2024.07.015.

Tang, Nicholas C., Jonathan C. Su, Yulia Shmidov, Garrett Kelly, Sonal Deshpande, Parul Sirohi, Nikhil Peterson, and Ashutosh Chilkoti. “Synthetic intrinsically disordered protein fusion tags that enhance protein solubility.” Nature Communications 15, no. 1 (May 2024): 3727. https://doi.org/10.1038/s41467-024-47519-7.

Li, Zongru, Qionghua Shen, Emery T. Usher, Andrew P. Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, et al. “Phase transition of GvpU regulates gas vesicle clustering in bacteria.” Nature Microbiology 9, no. 4 (April 2024): 1021–35. https://doi.org/10.1038/s41564-024-01648-3.

Walter, Vivien, Tatiana Schmatko, Pierre Muller, André P. Schroder, Sarah R. MacEwan, Ashutosh Chilkoti, and Carlos M. Marques. “Negative lipid membranes enhance the adsorption of TAT-decorated elastin-like polypeptide micelles.” Biophysical Journal 123, no. 7 (April 2024): 901–8. https://doi.org/10.1016/j.bpj.2024.03.001.

Albarghouthi, Faris M., Daria Semeniak, Iman Khanani, James L. Doherty, Brittany N. Smith, Matthew Salfity, Quentin MacFarlane, et al. “Addressing Signal Drift and Screening for Detection of Biomarkers with Carbon Nanotube Transistors.” ACS Nano, February 2024. https://doi.org/10.1021/acsnano.3c11679.

Strader, Rachel L., Yulia Shmidov, and Ashutosh Chilkoti. “Encoding Structure in Intrinsically Disordered Protein Biomaterials.” Accounts of Chemical Research 57, no. 3 (February 2024): 302–11. https://doi.org/10.1021/acs.accounts.3c00624.

Deshpande, Sonal, Yunqi Yang, Stefan Zauscher, and Ashutosh Chilkoti. “Enzymatic Synthesis of Aptamer-Polynucleotide Nanoparticles with High Anticancer Drug Loading for Targeted Delivery.” Biomacromolecules 25, no. 1 (January 2024): 155–64. https://doi.org/10.1021/acs.biomac.3c00888.