Publications

Zeng, Xiangze, Chengwen Liu, Martin J. Fossat, Pengyu Ren, Ashutosh Chilkoti, and Rohit V. Pappu. “Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures.” APL Materials 9, no. 2 (February 2021): 021119. https://doi.org/10.1063/5.0037438.

Li, Linying, C Wyatt Shields, Jin Huang, Yiqun Zhang, Korine A. Ohiri, Benjamin B. Yellen, Ashutosh Chilkoti, and Gabriel P. López. “Rapid capture of biomolecules from blood via stimuli-responsive elastomeric particles for acoustofluidic separation.” The Analyst 145, no. 24 (January 2021): 8087–96. https://doi.org/10.1039/d0an01164a.

Yousefpour, P., A. Varanko, R. Subrahmanyan, and A. Chilkoti. “Recombinant Fusion of Glucagon-Like Peptide-1 and an Albumin Binding Domain Provides Glycemic Control for a Week in Diabetic Mice.” Advanced Therapeutics 3, no. 10 (October 1, 2020). https://doi.org/10.1002/adtp.202000073.

Dodd, Rebecca D., Amanda Scherer, Wesley Huang, Gavin R. McGivney, Wade R. Gutierrez, Emily A. Laverty, Kathleen A. Ashcraft, et al. “Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.” Clin Cancer Res 26, no. 18 (September 15, 2020): 5036–47. https://doi.org/10.1158/1078-0432.CCR-19-2597.

Dzuricky, Michael, Bradley A. Rogers, Abdulla Shahid, Paul S. Cremer, and Ashutosh Chilkoti. “De novo engineering of intracellular condensates using artificial disordered proteins.” Nature Chemistry 12, no. 9 (September 2020): 814–25. https://doi.org/10.1038/s41557-020-0511-7.

Gilroy, C. A., M. E. Capozzi, A. K. Varanko, J. Tong, D. A. D’Alessio, J. E. Campbell, and A. Chilkoti. “Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia.” Sci Adv 6, no. 35 (August 2020): eaaz9890. https://doi.org/10.1126/sciadv.aaz9890.

Zeng, Xiangze, Alex S. Holehouse, Ashutosh Chilkoti, Tanja Mittag, and Rohit V. Pappu. “Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins.” Biophysical Journal 119, no. 2 (July 2020): 402–18. https://doi.org/10.1016/j.bpj.2020.06.014.

Cruz, Daniela F., Cassio M. Fontes, Daria Semeniak, Jiani Huang, Angus Hucknall, Ashutosh Chilkoti, and Maiken H. Mikkelsen. “Ultrabright Fluorescence Readout of an Inkjet-Printed Immunoassay Using Plasmonic Nanogap Cavities.” Nano Letters 20, no. 6 (June 2020): 4330–36. https://doi.org/10.1021/acs.nanolett.0c01051.

Varanko, Anastasia K., Jonathan C. Su, and Ashutosh Chilkoti. “Elastin-Like Polypeptides for Biomedical Applications.” Annual Review of Biomedical Engineering 22 (June 2020): 343–69. https://doi.org/10.1146/annurev-bioeng-092419-061127.

Banskota, Samagya, Soumen Saha, Jayanta Bhattacharya, Nadia Kirmani, Parisa Yousefpour, Michael Dzuricky, Nikita Zakharov, et al. “Genetically Encoded Stealth Nanoparticles of a Zwitterionic Polypeptide-Paclitaxel Conjugate Have a Wider Therapeutic Window than Abraxane in Multiple Tumor Models.” Nano Lett 20, no. 4 (April 8, 2020): 2396–2409. https://doi.org/10.1021/acs.nanolett.9b05094.

Saha, Soumen, Samagya Banskota, Stefan Roberts, Nadia Kirmani, and Ashutosh Chilkoti. “Engineering the Architecture of Elastin-Like Polypeptides: From Unimers to Hierarchical Self-Assembly.” Advanced Therapeutics 3, no. 3 (March 2020): 1900164. https://doi.org/10.1002/adtp.201900164.

Roberts, Stefan, Vincent Miao, Simone Costa, Joseph Simon, Garrett Kelly, Tejank Shah, Stefan Zauscher, and Ashutosh Chilkoti. “Complex microparticle architectures from stimuli-responsive intrinsically disordered proteins.” Nature Communications 11, no. 1 (March 2020): 1342. https://doi.org/10.1038/s41467-020-15128-9.

Williams, Nicholas X., Nathan Watson, Daniel Y. Joh, Ashutosh Chilkoti, and Aaron D. Franklin. “Aerosol jet printing of biological inks by ultrasonic delivery.” Biofabrication 12, no. 2 (February 2020): 025004. https://doi.org/10.1088/1758-5090/ab5cf5.

Varanko, Anastasia, Soumen Saha, and Ashutosh Chilkoti. “Recent trends in protein and peptide-based biomaterials for advanced drug delivery.” Advanced Drug Delivery Reviews 156 (January 2020): 133–87. https://doi.org/10.1016/j.addr.2020.08.008.

Heggestad, Jacob T., Cassio M. Fontes, Daniel Y. Joh, Angus M. Hucknall, and Ashutosh Chilkoti. “In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays.” Advanced Materials (Deerfield Beach, Fla.) 32, no. 2 (January 2020): e1903285. https://doi.org/10.1002/adma.201903285.

Wang, Jing, Junseon Min, Seyed Ali Eghtesadi, Ravi S. Kane, and Ashutosh Chilkoti. “Quantitative Study of the Interaction of Multivalent Ligand-Modified Nanoparticles with Breast Cancer Cells with Tunable Receptor Density.” ACS Nano 14, no. 1 (January 2020): 372–83. https://doi.org/10.1021/acsnano.9b05689.

Lee, J. S., R. T. Hill, A. Chilkoti, and W. L. Murphy. “Surface Patterning.” In Biomaterials Science: An Introduction to Materials in Medicine, 553–73, 2020. https://doi.org/10.1016/B978-0-12-816137-1.00037-4.

Wang, Jing, Soumen Saha, Jeffrey L. Schaal, Parisa Yousefpour, Xinghai Li, and Ashutosh Chilkoti. “Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles.” Nano Letters 19, no. 11 (November 2019): 7977–87. https://doi.org/10.1021/acs.nanolett.9b03141.

Dai, Zhuojun, Anna J. Lee, Stefan Roberts, Tatyana A. Sysoeva, Shuqiang Huang, Michael Dzuricky, Xiaoyu Yang, et al. “Versatile biomanufacturing through stimulus-responsive cell-material feedback.” Nature Chemical Biology 15, no. 10 (October 2019): 1017–24. https://doi.org/10.1038/s41589-019-0357-8.

Willems, Lione, Larissa van Westerveld, Stefan Roberts, Isaac Weitzhandler, Carlos Calcines Cruz, Armando Hernandez-Garcia, Ashutosh Chilkoti, Enrico Mastrobattista, John van der Oost, and Renko de Vries. “Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide.” Biomacromolecules 20, no. 10 (October 2019): 3641–47. https://doi.org/10.1021/acs.biomac.9b00512.

Garcia Quiroz, Felipe, Nan K. Li, Stefan Roberts, Patrick Weber, Michael Dzuricky, Isaac Weitzhandler, Yaroslava G. Yingling, and Ashutosh Chilkoti. “Intrinsically disordered proteins access a range of hysteretic phase separation behaviors.” Science Advances 5, no. 10 (October 2019): eaax5177. https://doi.org/10.1126/sciadv.aax5177.

Manzari, Mandana T., Gray R. Anderson, Kevin H. Lin, Ryan S. Soderquist, Merve Çakir, Mitchell Zhang, Chandler E. Moore, et al. “Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.” Sci Adv 5, no. 9 (September 2019): eaaw9162. https://doi.org/10.1126/sciadv.aaw9162.

Dzuricky, Michael, Sinan Xiong, Patrick Weber, and Ashutosh Chilkoti. “Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent.” Nano Letters 19, no. 9 (September 2019): 6124–32. https://doi.org/10.1021/acs.nanolett.9b02095.

Simon, Joseph R., Seyed Ali Eghtesadi, Michael Dzuricky, Lingchong You, and Ashutosh Chilkoti. “Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells.” Molecular Cell 75, no. 1 (July 2019): 66-75.e5. https://doi.org/10.1016/j.molcel.2019.05.010.

Varanko, Anastasia K., and Ashutosh Chilkoti. “Molecular and Materials Engineering for Delivery of Peptide Drugs to Treat Type 2 Diabetes.” Advanced Healthcare Materials 8, no. 12 (June 2019): e1801509. https://doi.org/10.1002/adhm.201801509.