Publications

2018

Yousefpour, Parisa, Jonathan R. McDaniel, Varun Prasad, Lucie Ahn, Xinghai Li, Rishi Subrahmanyan, Isaac Weitzhandler, Steven Suter, and Ashutosh Chilkoti. “Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy.” Nano Letters 18, no. 12 (December 2018): 7784–93. https://doi.org/10.1021/acs.nanolett.8b03558.

Roberts, Stefan, Tyler S. Harmon, Jeffrey L. Schaal, Vincent Miao, Kan Jonathan Li, Andrew Hunt, Yi Wen, et al. “Author Correction: Injectable tissue integrating networks from recombinant polypeptides with tunable order.” Nat Mater 17, no. 12 (December 2018): 1164. https://doi.org/10.1038/s41563-018-0233-z.

Roberts, Stefan, Tyler S. Harmon, Jeffrey L. Schaal, Vincent Miao, Kan Jonathan Li, Andrew Hunt, Yi Wen, et al. “Injectable tissue integrating networks from recombinant polypeptides with tunable order.” Nat Mater 17, no. 12 (December 2018): 1154–63. https://doi.org/10.1038/s41563-018-0182-6.

Ruff, Kiersten M., Stefan Roberts, Ashutosh Chilkoti, and Rohit V. Pappu. “Advances in Understanding Stimulus-Responsive Phase Behavior of Intrinsically Disordered Protein Polymers.” Journal of Molecular Biology 430, no. 23 (November 2018): 4619–35. https://doi.org/10.1016/j.jmb.2018.06.031.

Gu, Renpeng, Thomas Oweida, Yaroslava G. Yingling, Ashutosh Chilkoti, and Stefan Zauscher. “Enzymatic Synthesis of Nucleobase-Modified Single-Stranded DNA Offers Tunable Resistance to Nuclease Degradation.” Biomacromolecules 19, no. 8 (August 2018): 3525–35. https://doi.org/10.1021/acs.biomac.8b00816.

Li, Nan K., Stefan Roberts, Felipe Garcia Quiroz, Ashutosh Chilkoti, and Yaroslava G. Yingling. “Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides.” Biomacromolecules 19, no. 7 (July 2018): 2496–2505. https://doi.org/10.1021/acs.biomac.8b00099.

Dzuricky, Michael, Stefan Roberts, and Ashutosh Chilkoti. “Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins.” Biochemistry 57, no. 17 (May 2018): 2405–14. https://doi.org/10.1021/acs.biochem.8b00056.

Gilroy, Caslin A., Stefan Roberts, and Ashutosh Chilkoti. “Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action.” Journal of Controlled Release : Official Journal of the Controlled Release Society 277 (May 2018): 154–64. https://doi.org/10.1016/j.jconrel.2018.03.015.

Mozhdehi, Davoud, Kelli M. Luginbuhl, Joseph R. Simon, Michael Dzuricky, Rüdiger Berger, H Samet Varol, Fred C. Huang, et al. “Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly.” Nature Chemistry 10, no. 5 (May 2018): 496–505. https://doi.org/10.1038/s41557-018-0005-z.

Li, Linying, Nan K. Li, Qing Tu, Owen Im, Chia-Kuei Mo, Wei Han, William H. Fuss, et al. “Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.” Biomacromolecules 19, no. 2 (February 2018): 298–306. https://doi.org/10.1021/acs.biomac.7b01307.

Costa, Simone A., Joseph R. Simon, Miriam Amiram, Lei Tang, Stefan Zauscher, Eric M. Brustad, Farren J. Isaacs, and Ashutosh Chilkoti. “Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides.” Advanced Materials (Deerfield Beach, Fla.) 30, no. 5 (February 2018). https://doi.org/10.1002/adma.201704878.

Mastria, Eric M., Leon Y. Cai, Matthew J. Kan, Xinghai Li, Jeffrey L. Schaal, Steven Fiering, Michael D. Gunn, Mark W. Dewhirst, Smita K. Nair, and Ashutosh Chilkoti. “Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.” J Control Release 269 (January 10, 2018): 364–73. https://doi.org/10.1016/j.jconrel.2017.11.021.

2017

Luginbuhl, Kelli M., Davoud Mozhdehi, Michael Dzuricky, Parisa Yousefpour, Fred C. Huang, Nicholas R. Mayne, Kristen L. Buehne, and Ashutosh Chilkoti. “Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs.” Angewandte Chemie (International Ed. in English) 56, no. 45 (November 2017): 13979–84. https://doi.org/10.1002/anie.201704625.

Wang, Jing, Michael Dzuricky, and Ashutosh Chilkoti. “The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles.” Nano Letters 17, no. 10 (October 2017): 5995–6005. https://doi.org/10.1021/acs.nanolett.7b02225.

Bhattacharyya, Jayanta, Xiu-Rong Ren, Robert A. Mook, Jiangbo Wang, Ivan Spasojevic, Richard T. Premont, Xinghai Li, Ashutosh Chilkoti, and Wei Chen. “Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.” Nanoscale 9, no. 34 (August 31, 2017): 12709–17. https://doi.org/10.1039/c7nr01973d.

Wang, Jing, Jayanta Bhattacharyya, Eric Mastria, and Ashutosh Chilkoti. “A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles.” J Control Release 260 (August 28, 2017): 100–110. https://doi.org/10.1016/j.jconrel.2017.05.032.

Joh, Daniel Y., Angus M. Hucknall, Qingshan Wei, Kelly A. Mason, Margaret L. Lund, Cassio M. Fontes, Ryan T. Hill, et al. “Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood.” Proc Natl Acad Sci U S A 114, no. 34 (August 22, 2017): E7054–62. https://doi.org/10.1073/pnas.1703200114.

Weitzhandler, Isaac, Michael Dzuricky, Ingo Hoffmann, Felipe Garcia Quiroz, Michael Gradzielski, and Ashutosh Chilkoti. “Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides.” Biomacromolecules 18, no. 8 (August 2017): 2419–26. https://doi.org/10.1021/acs.biomac.7b00589.

Tang, Lei, Luis A. Navarro, Ashutosh Chilkoti, and Stefan Zauscher. “High-Molecular-Weight Polynucleotides by Transferase-Catalyzed Living Chain-Growth Polycondensation.” Angewandte Chemie (International Ed. in English) 56, no. 24 (June 2017): 6778–82. https://doi.org/10.1002/anie.201700991.

MacEwan, Sarah R., and Ashutosh Chilkoti. “From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.” Angewandte Chemie (International Ed. in English) 56, no. 24 (June 2017): 6712–33. https://doi.org/10.1002/anie.201610819.

Han, Wei, Ashutosh Chilkoti, and Gabriel P. López. “Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release.” Nanoscale 9, no. 18 (May 2017): 6178–86. https://doi.org/10.1039/c7nr00172j.

Bhattacharyya, Jayanta, Isaac Weitzhandler, Shihan Bryan Ho, Jonathan R. McDaniel, Xinghai Li, Lei Tang, Jinyao Liu, Mark Dewhirst, and Ashutosh Chilkoti. “Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy.” Adv Funct Mater 27, no. 12 (March 24, 2017). https://doi.org/10.1002/adfm.201605421.

Weinberger, A., V. Walter, S. R. MacEwan, T. Schmatko, P. Muller, A. P. Schroder, A. Chilkoti, and C. M. Marques. “Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes.” Scientific Reports 7 (March 6, 2017). https://doi.org/10.1038/srep43963.

Widder, Katharina, Sarah R. MacEwan, Elisabeth Garanger, Vanesa Núñez, Sébastien Lecommandoux, Ashutosh Chilkoti, and Dariush Hinderberger. “Characterisation of hydration and nanophase separation during the temperature response in hydrophobic/hydrophilic elastin-like polypeptide (ELP) diblock copolymers.” Soft Matter 13, no. 9 (March 2017): 1816–22. https://doi.org/10.1039/c6sm02427k.

Ozer, Imran, and Ashutosh Chilkoti. “Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins.” Bioconjugate Chemistry 28, no. 3 (March 2017): 713–23. https://doi.org/10.1021/acs.bioconjchem.6b00652.