Publications

Ozer, Imran, Anna Slezak, Parul Sirohi, Xinghai Li, Nikita Zakharov, Yunxin Yao, Jeffrey I. Everitt, et al. “An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug.” Biomaterials 294 (March 2023): 121985. https://doi.org/10.1016/j.biomaterials.2022.121985.

Olson, Lyra B., Nicole I. Hunter, Rachel E. Rempel, Haixiang Yu, Diane M. Spencer, Cynthia Z. Sullenger, William S. Greene, et al. “Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity.” IScience 25, no. 12 (December 22, 2022): 105542. https://doi.org/10.1016/j.isci.2022.105542.

J. Haley, Jones, J. B. , Petraki, S. , Callander, M. , Shrestha, S. , Springfield, E. , Adamson, L. , Chilkoti, A. , Dzuricky, M. J. , and Luginbuhl, K. M. , “IsoTag™AAV: an innovative, scalable & non-chromatographic method for streamlined AAV manufacturing”, Cell & Gene Therapy Insights, vol. 8, no. 10, pp. 1287-1300, 2022.

Schaal, Jeffrey L., Jayanta Bhattacharyya, Jeremy Brownstein, Kyle C. Strickland, Garrett Kelly, Soumen Saha, Joshua Milligan, et al. “Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours.” Nat Biomed Eng 6, no. 10 (October 2022): 1148–66. https://doi.org/10.1038/s41551-022-00949-4.

Roden, Christine A., Yifan Dai, Catherine A. Giannetti, Ian Seim, Myungwoon Lee, Rachel Sealfon, Grace A. McLaughlin, et al. “Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures.” Nucleic Acids Res 50, no. 14 (August 12, 2022): 8168–92. https://doi.org/10.1093/nar/gkac596.

Saha, Soumen, Samagya Banskota, Jianqiao Liu, Nikita Zakharov, Michael Dzuricky, Xinghai Li, Ping Fan, et al. “Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model.” Nano Lett 22, no. 14 (July 27, 2022): 5898–5908. https://doi.org/10.1021/acs.nanolett.2c01850.

Lin, Kevin H., Justine C. Rutter, Abigail Xie, Shane T. Killarney, Camille Vaganay, Chaima Benaksas, Frank Ling, et al. “P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.” Nat Cancer 3, no. 7 (July 2022): 837–51. https://doi.org/10.1038/s43018-022-00394-x.

Kinnamon, David S., Jacob T. Heggestad, Jason Liu, and Ashutosh Chilkoti. “Technologies for Frugal and Sensitive Point-of-Care Immunoassays.” Annual Review of Analytical Chemistry (Palo Alto, Calif.) 15, no. 1 (June 2022): 123–49. https://doi.org/10.1146/annurev-anchem-061020-123817.

Milligan, Joshua J., Soumen Saha, Irene C. Jenkins, and Ashutosh Chilkoti. “Genetically encoded elastin-like polypeptide nanoparticles for drug delivery.” Current Opinion in Biotechnology 74 (April 2022): 146–53. https://doi.org/10.1016/j.copbio.2021.11.006.

Ozer, Imran, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, et al. “Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.” Adv Sci (Weinh) 9, no. 11 (April 2022): e2103672. https://doi.org/10.1002/advs.202103672.

Kelly, Garrett, Joshua J. Milligan, Eric M. Mastria, Sarah Kim, Stephanie R. Zelenetz, Jarrett Dobbins, Leon Y. Cai, Xinghai Li, Smita K. Nair, and Ashutosh Chilkoti. “Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot.” J Control Release 343 (March 2022): 267–76. https://doi.org/10.1016/j.jconrel.2022.01.024.

Ozer, Imran, George A. Pitoc, Juliana M. Layzer, Angelo Moreno, Lyra B. Olson, Kyle D. Layzer, Angus M. Hucknall, Bruce A. Sullenger, and Ashutosh Chilkoti. “PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response.” Adv Mater 34, no. 10 (March 2022): e2107852. https://doi.org/10.1002/adma.202107852.

Heggestad, Jacob T., David S. Kinnamon, Jason Liu, Daniel Y. Joh, Cassio M. Fontes, Qingshan Wei, Aydogan Ozcan, Angus M. Hucknall, and Ashutosh Chilkoti. “Smartphone Enabled Point-of-Care Detection of Serum Biomarkers.” Methods in Molecular Biology (Clifton, N.J.) 2393 (January 2022): 343–65. https://doi.org/10.1007/978-1-0716-1803-5_19.

Heggestad, Jacob T., Rhett J. Britton, David S. Kinnamon, Simone A. Wall, Daniel Y. Joh, Angus M. Hucknall, Lyra B. Olson, et al. “Rapid test to assess the escape of SARS-CoV-2 variants of concern.” Sci Adv 7, no. 49 (December 3, 2021): eabl7682. https://doi.org/10.1126/sciadv.abl7682.

J. T. Heggestad, Kinnamon, D. S. , Liu, J. , Joh, D. Y. , Fontes, C. M. , Wei, Q. , Ozcan, A. , Hucknall, A. M. , and Chilkoti, A. , Methods in Molecular BiologyBiomedical Engineering TechnologiesSmartphone Enabled Point-of-Care Detection of Serum Biomarkers, vol. 2393. New York, NY: Springer US, 2021, pp. 343 - 365.

Weber, Patrick, Michael Dzuricky, Junseon Min, Irene Jenkins, and Ashutosh Chilkoti. “Concentration-Independent Multivalent Targeting of Cancer Cells by Genetically Encoded Core-Crosslinked Elastin/Resilin-like Polypeptide Micelles.” Biomacromolecules 22, no. 10 (October 2021): 4347–56. https://doi.org/10.1021/acs.biomac.1c00897.

Joh, Daniel Y., Jacob T. Heggestad, Shengwei Zhang, Gray R. Anderson, Jayanta Bhattacharyya, Suzanne E. Wardell, Simone A. Wall, et al. “Author Correction: Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates.” NPJ Breast Cancer 7, no. 1 (September 17, 2021): 126. https://doi.org/10.1038/s41523-021-00335-4.

Navarro, Luis A., Justin J. Ryan, Michael Dzuricky, Michael Gradzielski, Ashutosh Chilkoti, and Stefan Zauscher. “Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions.” Biomacromolecules 22, no. 9 (September 2021): 3827–38. https://doi.org/10.1021/acs.biomac.1c00672.

Joh, Daniel Y., Jacob T. Heggestad, Shengwei Zhang, Gray R. Anderson, Jayanta Bhattacharyya, Suzanne E. Wardell, Simone A. Wall, et al. “Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates.” NPJ Breast Cancer 7, no. 1 (July 2, 2021): 85. https://doi.org/10.1038/s41523-021-00290-0.

Jenkins, Irene C., Joshua J. Milligan, and Ashutosh Chilkoti. “Genetically Encoded Elastin-Like Polypeptides for Drug Delivery.” Advanced Healthcare Materials 10, no. 13 (July 2021): e2100209. https://doi.org/10.1002/adhm.202100209.

Shapiro, Daniel Mark, Max Ney, Seyed Ali Eghtesadi, and Ashutosh Chilkoti. “Protein Phase Separation Arising from Intrinsic Disorder: First-Principles to Bespoke Applications.” The Journal of Physical Chemistry. B 125, no. 25 (July 2021): 6740–59. https://doi.org/10.1021/acs.jpcb.1c01146.

Heggestad, Jacob T., David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Solomon Oshabaheebwa, et al. “Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.” Sci Adv 7, no. 26 (June 2021). https://doi.org/10.1126/sciadv.abg4901.

Fontes, Cassio M., Barbara D. Lipes, Jason Liu, Krystle N. Agans, Aiwei Yan, Patricia Shi, Daniela F. Cruz, et al. “Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR.” Sci Transl Med 13, no. 588 (April 7, 2021). https://doi.org/10.1126/scitranslmed.abd9696.

Hainline, Kelly M., Lucas S. Shores, Nicole L. Votaw, Zachary J. Bernstein, Sean H. Kelly, Chelsea N. Fries, Marisha S. Madhira, Caslin A. Gilroy, Ashutosh Chilkoti, and Joel H. Collier. “Modular complement assemblies for mitigating inflammatory conditions.” Proceedings of the National Academy of Sciences of the United States of America 118, no. 15 (April 2021): e2018627118. https://doi.org/10.1073/pnas.2018627118.

Laaß, Katharina, Felipe García Quiroz, Johannes Hunold, Stefan Roberts, Ashutosh Chilkoti, and Dariush Hinderberger. “Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins.” Biomacromolecules 22, no. 2 (February 2021): 1015–25. https://doi.org/10.1021/acs.biomac.0c01768.