Publications

Semeniak, Daria, Daniela F. Cruz, Ashutosh Chilkoti, and Maiken H. Mikkelsen. “Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.” Advanced Materials (Deerfield Beach, Fla.) 35, no. 34 (August 2023): e2107986. https://doi.org/10.1002/adma.202107986.

Vahabi, Hamed, Jason Liu, Yifan Dai, Daniel Y. Joh, Rhett Britton, Jacob Heggestad, David Kinnamon, Satyam Rajput, and Ashutosh Chilkoti. “A gravity-driven droplet fluidic point-of-care test.” Device 1, no. 1 (July 2023): 100009. https://doi.org/10.1016/j.device.2023.100009.

Kinnamon, David S., Jacob T. Heggestad, Jason Liu, Thu Nguyen, Vo Ly, Angus M. Hucknall, Cassio M. Fontes, et al. “Environmentally Resilient Microfluidic Point-of-Care Immunoassay Enables Rapid Diagnosis of Talaromycosis.” ACS Sens 8, no. 6 (June 23, 2023): 2228–36. https://doi.org/10.1021/acssensors.3c00209.

Dai, Yifan, Christian F. Chamberlayne, Marco S. Messina, Christopher J. Chang, Richard N. Zare, Lingchong You, and Ashutosh Chilkoti. “Interface of biomolecular condensates modulates redox reactions.” Chem 9, no. 6 (June 2023): 1594–1609. https://doi.org/10.1016/j.chempr.2023.04.001.

Burrow, Damon T., Jacob T. Heggestad, David S. Kinnamon, and Ashutosh Chilkoti. “Engineering Innovative Interfaces for Point-of-Care Diagnostics.” Current Opinion in Colloid & Interface Science, June 2023, 101718. https://doi.org/10.1016/j.cocis.2023.101718.

Heggestad, Jacob T., Rhett J. Britton, David S. Kinnamon, Jason Liu, Jack G. Anderson, Daniel Y. Joh, Zachary Quinn, et al. “COVID-19 Diagnosis and SARS-CoV-2 Strain Identification by a Rapid, Multiplexed, Point-of-Care Antibody Microarray.” Anal Chem 95, no. 13 (April 4, 2023): 5610–17. https://doi.org/10.1021/acs.analchem.2c05180.

Y. Dai, You, L. , and Chilkoti, A. , “Engineering synthetic biomolecular condensates”, Nature Reviews Bioengineering, 2023.

Dai, Yifan, Mina Farag, Dongheon Lee, Xiangze Zeng, Kyeri Kim, Hye-In Son, Xiao Guo, et al. “Programmable synthetic biomolecular condensates for cellular control.” Nature Chemical Biology 19, no. 4 (April 2023): 518–28. https://doi.org/10.1038/s41589-022-01252-8.

Dai, Yifan, Lingchong You, and Ashutosh Chilkoti. “Engineering synthetic biomolecular condensates.” Nature Reviews Bioengineering, April 2023, 1–15. https://doi.org/10.1038/s44222-023-00052-6.

Ozer, Imran, Anna Slezak, Parul Sirohi, Xinghai Li, Nikita Zakharov, Yunxin Yao, Jeffrey I. Everitt, et al. “An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug.” Biomaterials 294 (March 2023): 121985. https://doi.org/10.1016/j.biomaterials.2022.121985.

Olson, Lyra B., Nicole I. Hunter, Rachel E. Rempel, Haixiang Yu, Diane M. Spencer, Cynthia Z. Sullenger, William S. Greene, et al. “Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity.” IScience 25, no. 12 (December 22, 2022): 105542. https://doi.org/10.1016/j.isci.2022.105542.

J. Haley, Jones, J. B. , Petraki, S. , Callander, M. , Shrestha, S. , Springfield, E. , Adamson, L. , Chilkoti, A. , Dzuricky, M. J. , and Luginbuhl, K. M. , “IsoTag™AAV: an innovative, scalable & non-chromatographic method for streamlined AAV manufacturing”, Cell & Gene Therapy Insights, vol. 8, no. 10, pp. 1287-1300, 2022.

Schaal, Jeffrey L., Jayanta Bhattacharyya, Jeremy Brownstein, Kyle C. Strickland, Garrett Kelly, Soumen Saha, Joshua Milligan, et al. “Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours.” Nat Biomed Eng 6, no. 10 (October 2022): 1148–66. https://doi.org/10.1038/s41551-022-00949-4.

Roden, Christine A., Yifan Dai, Catherine A. Giannetti, Ian Seim, Myungwoon Lee, Rachel Sealfon, Grace A. McLaughlin, et al. “Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures.” Nucleic Acids Res 50, no. 14 (August 12, 2022): 8168–92. https://doi.org/10.1093/nar/gkac596.

Saha, Soumen, Samagya Banskota, Jianqiao Liu, Nikita Zakharov, Michael Dzuricky, Xinghai Li, Ping Fan, et al. “Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model.” Nano Lett 22, no. 14 (July 27, 2022): 5898–5908. https://doi.org/10.1021/acs.nanolett.2c01850.

Lin, Kevin H., Justine C. Rutter, Abigail Xie, Shane T. Killarney, Camille Vaganay, Chaima Benaksas, Frank Ling, et al. “P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.” Nat Cancer 3, no. 7 (July 2022): 837–51. https://doi.org/10.1038/s43018-022-00394-x.

Kinnamon, David S., Jacob T. Heggestad, Jason Liu, and Ashutosh Chilkoti. “Technologies for Frugal and Sensitive Point-of-Care Immunoassays.” Annual Review of Analytical Chemistry (Palo Alto, Calif.) 15, no. 1 (June 2022): 123–49. https://doi.org/10.1146/annurev-anchem-061020-123817.

Ozer, Imran, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, et al. “Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.” Adv Sci (Weinh) 9, no. 11 (April 2022): e2103672. https://doi.org/10.1002/advs.202103672.

Milligan, Joshua J., Soumen Saha, Irene C. Jenkins, and Ashutosh Chilkoti. “Genetically encoded elastin-like polypeptide nanoparticles for drug delivery.” Current Opinion in Biotechnology 74 (April 2022): 146–53. https://doi.org/10.1016/j.copbio.2021.11.006.

Kelly, Garrett, Joshua J. Milligan, Eric M. Mastria, Sarah Kim, Stephanie R. Zelenetz, Jarrett Dobbins, Leon Y. Cai, Xinghai Li, Smita K. Nair, and Ashutosh Chilkoti. “Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot.” J Control Release 343 (March 2022): 267–76. https://doi.org/10.1016/j.jconrel.2022.01.024.

Ozer, Imran, George A. Pitoc, Juliana M. Layzer, Angelo Moreno, Lyra B. Olson, Kyle D. Layzer, Angus M. Hucknall, Bruce A. Sullenger, and Ashutosh Chilkoti. “PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response.” Adv Mater 34, no. 10 (March 2022): e2107852. https://doi.org/10.1002/adma.202107852.

Heggestad, Jacob T., David S. Kinnamon, Jason Liu, Daniel Y. Joh, Cassio M. Fontes, Qingshan Wei, Aydogan Ozcan, Angus M. Hucknall, and Ashutosh Chilkoti. “Smartphone Enabled Point-of-Care Detection of Serum Biomarkers.” Methods in Molecular Biology (Clifton, N.J.) 2393 (January 2022): 343–65. https://doi.org/10.1007/978-1-0716-1803-5_19.

Heggestad, Jacob T., Rhett J. Britton, David S. Kinnamon, Simone A. Wall, Daniel Y. Joh, Angus M. Hucknall, Lyra B. Olson, et al. “Rapid test to assess the escape of SARS-CoV-2 variants of concern.” Sci Adv 7, no. 49 (December 3, 2021): eabl7682. https://doi.org/10.1126/sciadv.abl7682.

J. T. Heggestad, Kinnamon, D. S. , Liu, J. , Joh, D. Y. , Fontes, C. M. , Wei, Q. , Ozcan, A. , Hucknall, A. M. , and Chilkoti, A. , Methods in Molecular BiologyBiomedical Engineering TechnologiesSmartphone Enabled Point-of-Care Detection of Serum Biomarkers, vol. 2393. New York, NY: Springer US, 2021, pp. 343 - 365.

Weber, Patrick, Michael Dzuricky, Junseon Min, Irene Jenkins, and Ashutosh Chilkoti. “Concentration-Independent Multivalent Targeting of Cancer Cells by Genetically Encoded Core-Crosslinked Elastin/Resilin-like Polypeptide Micelles.” Biomacromolecules 22, no. 10 (October 2021): 4347–56. https://doi.org/10.1021/acs.biomac.1c00897.