Publications

Li, Linying, Chia-Kuei Mo, Ashutosh Chilkoti, Gabriel P. Lopez, and Nick J. Carroll. “Creating cellular patterns using genetically engineered, gold- and cell-binding polypeptides.” Biointerphases 11, no. 2 (June 2016): 021009. https://doi.org/10.1116/1.4952452.

Schaal, Jeffrey L., Xinghai Li, Eric Mastria, Jayanta Bhattacharyya, Michael R. Zalutsky, Ashutosh Chilkoti, and Wenge Liu. “Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy.” J Control Release 228 (April 28, 2016): 58–66. https://doi.org/10.1016/j.jconrel.2016.02.040.

Tang, Nicholas C., and Ashutosh Chilkoti. “Combinatorial codon scrambling enables scalable gene synthesis and amplification of repetitive proteins.” Nature Materials 15, no. 4 (April 2016): 419–24. https://doi.org/10.1038/nmat4521.

Nawroth, Jonas F., Jonathan R. McDaniel, Ashutosh Chilkoti, Rainer Jordan, and Robert Luxenhofer. “Maleimide-Functionalized Poly(2-Oxazoline)s and Their Conjugation to Elastin-Like Polypeptides.” Macromolecular Bioscience 16, no. 3 (March 2016): 322–33. https://doi.org/10.1002/mabi.201500376.

Mukerji, Ratul, Jeffrey Schaal, Xinghai Li, Jayanta Bhattacharyya, Daisuke Asai, Michael R. Zalutsky, Ashutosh Chilkoti, and Wenge Liu. “Spatiotemporally photoradiation-controlled intratumoral depot for combination of brachytherapy and photodynamic therapy for solid tumor.” Biomaterials 79 (February 2016): 79–87. https://doi.org/10.1016/j.biomaterials.2015.11.064.

Qi, Yizhi, Antonina Simakova, Nancy J. Ganson, Xinghai Li, Kelli M. Luginbuhl, Imran Özer, Wenge Liu, Michael S. Hershfield, Krzysztof Matyjaszewski, and Ashutosh Chilkoti. “A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity.” Nat Biomed Eng 1 (2016). https://doi.org/10.1038/s41551-016-0002.

Bhattacharyya, J., J. J. Bellucci, and A. Chilkoti. “Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering.” In Biomaterials from Nature for Advanced Devices and Therapies, 106–26, 2016. https://doi.org/10.1002/9781119126218.ch7.

Quiroz, Felipe García, and Ashutosh Chilkoti. “Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers.” Nature Materials 14, no. 11 (November 2015): 1164–71. https://doi.org/10.1038/nmat4418.

Li, Nan K., William H. Fuss, Lei Tang, Renpeng Gu, Ashutosh Chilkoti, Stefan Zauscher, and Yaroslava G. Yingling. “Prediction of solvent-induced morphological changes of polyelectrolyte diblock copolymer micelles.” Soft Matter 11, no. 42 (November 2015): 8236–45. https://doi.org/10.1039/c5sm01742d.

Bhattacharjee, Somnath, Wenge Liu, Wei-Han Wang, Isaac Weitzhandler, Xinghai Li, Yizhi Qi, Jinyao Liu, Yan Pang, Donald F. Hunt, and Ashutosh Chilkoti. “Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation.” Chembiochem : A European Journal of Chemical Biology 16, no. 17 (November 2015): 2451–55. https://doi.org/10.1002/cbic.201500439.

Abedini-Nassab, Roozbeh, Daniel Y. Joh, Melissa A. Van Heest, John S. Yi, Cody Baker, Zohreh Taherifard, David M. Margolis, et al. “Characterizing the Switching Thresholds of Magnetophoretic Transistors.” Adv Mater 27, no. 40 (October 28, 2015): 6176–80. https://doi.org/10.1002/adma.201502352.

Qi, Yizhi, and Ashutosh Chilkoti. “Protein-polymer conjugation-moving beyond PEGylation.” Current Opinion in Chemical Biology 28 (October 2015): 181–93. https://doi.org/10.1016/j.cbpa.2015.08.009.

Garanger, E., S. R. MacEwan, O. Sandre, A. Brûlet, L. Bataille, A. Chilkoti, and S. Lecommandoux. “Structural Evolution of a Stimulus-Responsive Diblock Polypeptide Micelle by Temperature Tunable Compaction of its Core.” Macromolecules 48, no. 18 (September 22, 2015): 6617–27. https://doi.org/10.1021/acs.macromol.5b01371.

Roberts, Stefan, Michael Dzuricky, and Ashutosh Chilkoti. “Elastin-like polypeptides as models of intrinsically disordered proteins.” FEBS Letters 589, no. 19 Pt A (September 2015): 2477–86. https://doi.org/10.1016/j.febslet.2015.08.029.

Bhattacharyya, Jayanta, Joseph J. Bellucci, Isaac Weitzhandler, Jonathan R. McDaniel, Ivan Spasojevic, Xinghai Li, Chao-Chieh Lin, Jen-Tsan Ashley Chi, and Ashutosh Chilkoti. “A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models.” Nat Commun 6 (August 4, 2015): 7939. https://doi.org/10.1038/ncomms8939.

Han, Wei, Sarah R. MacEwan, Ashutosh Chilkoti, and Gabriel P. López. “Bio-inspired synthesis of hybrid silica nanoparticles templated from elastin-like polypeptide micelles.” Nanoscale 7, no. 28 (July 2015): 12038–44. https://doi.org/10.1039/c5nr01407g.

Mastria, Eric M., Mingnan Chen, Jonathan R. McDaniel, Xinghai Li, Jinho Hyun, Mark W. Dewhirst, and Ashutosh Chilkoti. “Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.” J Control Release 208 (June 28, 2015): 52–58. https://doi.org/10.1016/j.jconrel.2015.01.033.

Ghoorchian, A., J. R. Simon, B. Bharti, W. Han, X. Zhao, A. Chilkoti, and G. P. Lõpez. “Bioinspired reversibly cross-linked hydrogels comprising polypeptide micelles exhibit enhanced mechanical properties.” Advanced Functional Materials 25, no. 21 (June 1, 2015): 3122–30. https://doi.org/10.1002/adfm.201500699.

Kimmerling, K. A., B. D. Furman, D. S. Mangiapani, M. A. Moverman, S. M. Sinclair, J. L. Huebner, A. Chilkoti, et al. “Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis.” Eur Cell Mater 29 (January 31, 2015): 124–39. https://doi.org/10.22203/ecm.v029a10.

Hassouneh, Wafa, Ekaterina B. Zhulina, Ashutosh Chilkoti, and Michael Rubinstein. “Elastin-like Polypeptide Diblock Copolymers Self-Assemble into Weak Micelles.” Macromolecules, 2015. https://doi.org/10.1021/acs.macromol.5b00431.

Liu, Jinyao, Wenge Liu, Isaac Weitzhandler, Jayanta Bhattacharyya, Xinghai Li, Jing Wang, Yizhi Qi, Somnath Bhattacharjee, and Ashutosh Chilkoti. “Ring-opening polymerization of prodrugs: a versatile approach to prepare well-defined drug-loaded nanoparticles.” Angewandte Chemie (International Ed. in English) 54, no. 3 (January 2015): 1002–6. https://doi.org/10.1002/anie.201409293.

Bellucci, Joseph J., Jayanta Bhattacharyya, and Ashutosh Chilkoti. “A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins.” Angewandte Chemie (International Ed. in English) 54, no. 2 (January 2015): 441–45. https://doi.org/10.1002/anie.201408126.

McDaniel, Jonathan R., Isaac Weitzhandler, Sylvain Prevost, Kevin B. Vargo, Marie-Sousai Appavou, Daniel A. Hammer, Michael Gradzielski, and Ashutosh Chilkoti. “Noncanonical self-assembly of highly asymmetric genetically encoded polypeptide amphiphiles into cylindrical micelles.” Nano Letters 14, no. 11 (November 2014): 6590–98. https://doi.org/10.1021/nl503221p.

Li, Nan K., Felipe García Quiroz, Carol K. Hall, Ashutosh Chilkoti, and Yaroslava G. Yingling. “Molecular description of the LCST behavior of an elastin-like polypeptide.” Biomacromolecules 15, no. 10 (October 2014): 3522–30. https://doi.org/10.1021/bm500658w.

Hill, Ryan T., Klaudia M. Kozek, Angus Hucknall, David R. Smith, and Ashutosh Chilkoti. “Nanoparticle-Film Plasmon Ruler Interrogated with Transmission Visible Spectroscopy.” ACS Photonics 1, no. 10 (October 2014): 974–84. https://doi.org/10.1021/ph500190q.